The Effect of 7-Methylguanine on the Dna and the Related Processes

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[Type the company name] | The effect of 7-Methylguanine on the DNA and the Related Processes | Mutation & Disease | | | |

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Abstract
Alkylation is the additon of an alkyl group and it usually follows the structural formula of (CnHn+1). Therefore methylation which is the addition of a CH3 comes to highlight the simplest form of the alkylation process at which there is only 1-Carbon. The effect of methylation and alkylation in general is studied most precisely on the nucleic bases of the DNA double helix. The methyl group attaches to the 7-position of the purine ring; guanine resulting in structural and chemical changes within the base as well as the whole of he DNA. This consequcntly has a range of implication on the function of the DNA and the processes that are kean to occur for development. The damage of the 7-Methylguanine is studied specifically through numerous research projects that aim to link this damage to other mutations. Until now scientists and researchers were able to identify age and cancer as prime mutations of this damage, and the field is working for developing and enhancing a proper theory that would explain the repair mechanism invloving the specific proteins.
Methylation has harmful effects and its fatal jeapordy on the rick of humans has become inevitable. 7-Methylgunine maybe of little threat due to the minor and insignificant effect it has, but it studies have showed that this damage is capable of developing more harmful structures, which pose a risk given the extent of the mutation they propose.

Methylation of DNA nitrogenous bases is a recurring mutation that has many effects on the structure of the base and the double helix as a whole. The addition of the simple alkyl group; CH3 has minor as well as significant changes on the DNA. Methylation of the base pair is caused by numerous factors, these ranges…...

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